Early detection and progression of subclinical atherosclerosis and cardiovascular health

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Years of study
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Scientific Publications
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Researchers
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Participants

Our team

Dr. Valentín Fuster

Principal Investigator

Dr. Borja Ibáñez

Co-Principal Investigator

Recent publications

Subclinical atherosclerosis and brain health in midlife: Rationale and design of the PESA-Brain study

American Heart Journal (AHJ)

Coronary Microvascular Function in Asymptomatic Middle-Aged Individuals With Cardiometabolic Risk Factors

Journal of the American College of Cardiology - Cardiovascular Imaging

Unidirectional association of clonal hematopoiesis with atherosclerosis development

Nature Medicine

Association between subclinical atherosclerosis burden and unrecognized myocardial infarction detected by cardiac magnetic resonance in middle-aged adults

European Heart Journal - Cardiovascular Imaging

Apolipoprotein E-ε2 and Resistance to Atherosclerosis in Midlife: The PESA Observational Study

Circulation Research

Early insulin resistance in normoglycemic low-risk individuals is associated with subclinical atherosclerosis

Cardiovascular Diabetology

Determinants of Progression and Regression of Subclinical Atherosclerosis Over 6 Years

Journal of the American College of Cardiology (JACC)

Cardiac Insulin Resistance in Subjects With Metabolic Syndrome Traits and Early Subclinical Atherosclerosis

Diabetes Care

Recent news

A study from CNIC reveals how risk factors and subclinical atherosclerosis affect heart microcirculation in asymptomatic middle-aged individuals. The research, published in JACC: Cardiovascular Imaging, highlights the importance of assessing the heart vessels’ ability to regulate blood flow and predict...
Two studies carried out at the CNIC provide key information about a newly identified cardiovascular risk factor, clonal hematopoiesis, and its treatment with the ancient medication colchicine
Guiomar Mendieta has been awarded the 2023 William W. Parmley Young Author Achievement Award for a paper published in JACC that is considered to an outstanding contribution in the field of atherosclerosis
The most potent genetic risk factor for Alzheimer disease, APOE4, is associated with an elevated risk of developing subclinical atherosclerosis in middle age, whereas the Alzheimer-protective variant of the same gene, APOE2, protects against subclinical atherosclerosis
Atherosclerosis, previously believed to be an irreversible progressive disease, can be reversed if risk factors are contolled early enough
A new CNIC study shows that low-grade systemic inflammation triggered by subcinical atherosclerosis accelerates epigenetic aging in otherwise healthy young individuals
In Spain, only 16% of professionals in the STEM area are women. On this March 8th we have prepared this action so that young people can know about 4 women from the CNIC who are part of the PESA HEALTH...
Adherence to a workplace cardiovascular health-promotion program improves lifestyle and risk factors in healthy individuals
This new discovery paves the way to new research avenues toward the discovery of interventions to prevent or arrest atherosclerosis
Scientists at the CNIC have led the development of a new three-dimensional ultrasound method that improves the assessment of cardiovascular risk in healthy individuals
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Contact us

The PESA-H study is carried out in the following centres

Santander Medical Centre

Av. de Ciudad de Santander, 44 | 28660 – Boadilla del Monte (Madrid, España)

Spanish National Centre for Cardiovascular Research (CNIC)

C/ Melchor Fernández Almagro, 328029 – Madrid (España)